User: I need a molecule with high binding affinity to a specific protein target. Can you design a molecule for me?
ChatGPT: Sure, what is the protein target and what are the desired properties of the molecule?
User: The protein target is an enzyme that is involved in a specific disease pathway. I need a molecule that can inhibit the enzyme with high potency and selectivity.
ChatGPT: Based on the protein target and desired properties, I recommend a scaffold-based approach. One potential scaffold is a pyrazole ring system, which has been shown to have good binding affinity to a variety of enzyme targets. We can modify the pyrazole scaffold with various functional groups to optimize binding affinity and selectivity.
