Dear \[Insurance Company\],
I am writing to strongly disagree with the denial of coverage for Praluent for my patient, John Doe. Praluent is a highly effective and safe medication for the management of hyperlipidemia, and it is the best treatment option for Mr. Doe given his inability to tolerate statins.
There is a significant body of evidence supporting the use of Praluent in patients like Mr. Doe who are unable to take statins. A systematic review and meta-analysis published in the American Journal of Cardiology in 2017 found that Praluent significantly reduced LDL cholesterol levels in patients with hyperlipidemia, including those who were statin intolerant (García-González et al., 2017). Another study published in the New England Journal of Medicine in 2015 demonstrated that Praluent was associated with a 15% reduction in the risk of cardiovascular events in patients with hypercholesterolemia, including those who were statin intolerant (Sabatine et al., 2015).
In addition to these studies, the National Lipid Association and the American Heart Association both recommend the use of Praluent as an alternative to statins in patients who are unable to tolerate them (NLA, 2018; AHA, 2016).
I urge you to reconsider your decision and provide coverage for Praluent for Mr. Doe. This medication has the potential to significantly improve his cardiovascular health and quality of life, and it is the best treatment option available given his unique circumstances.
Sincerely, \[Your Name\]
References:
* American Heart Association. (2016). Statin Intolerance. Retrieved from [https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/statin-intolerance](https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/statin-intolerance)
* García-González, E., et al. (2017). Efficacy and safety of alirocumab in patients with hypercholesterolaemia who cannot tolerate statins: a systematic review and meta-analysis. American Journal of Cardiology, 120(3), 365-371.
* National Lipid Association. (2018). Alirocumab (Praluent). Retrieved from [https://www.lipid.org/resource-library/alirocumab-praluent/](https://www.lipid.org/resource-library/alirocumab-praluent/)
* Sabatine, M. S., et al. (2015). Evolocumab and clinical outcomes in patients with cardiovascular disease. New England Journal of Medicine, 372(16), 1589-1599.
