On behalf of the 21st AIAI (Artificial Intelligence Applications and Innovations) 2025 Organizing and Scientific Committee, it is a real honor and pleasure to welcome all Artificial Intelligence scholars who are looking for a well-established and prestigious forum to communicate and disseminate the innovative advances of their research. It is a fact that AI is continuously digging its way in a vast number of diverse scientific domains. AIAI aims to provide a forum for delegates from both academia and industry, who wish to share pioneer ideas, to get to know each other better and to present their research. Moreover, it aims to offer a deep glimpse into the future and to examine important AI ethical aspects.